Genetic Therapies Could Give Superior Mesothelioma Treatments in Comparison to Radiation Therapy

Oncologists and other cancer doctors choose what type of treatment to pursue to each patient. The options are endless. There is no one size fits all treatment regimen for peritoneal mesothelioma victims. This is due to the cancers high mortality rate, rareness, low treatment success rate, and small number of studies to provide meaningful statistics.

The prospects for mesothelioma patients have been grim, but doctors have recently made progress. Traditional treatments for cancer are surgery (removing the tumor and surrounding tissue), radiation (killing the cancerous cells with radiation), and chemotherapy (poisoning the cancerous cells.) Each one of these methods have problems. Mesothelioma patients treated with traditional radiation therapy have not responded well to it. Researches, concerned about damage to healthy tissue, are looking for ways to aim radiation directly at tumors.

Surgery takes out the mesothelial cancerous tissue around the tumor. This surgery is extensive and it is not clear how much the patient benefits. The usual chemotherapy cocktails effective on other cancers are not effective on mesothelioma, and different mixtures of these drugs have not been successful. As with radiation, research is going toward controlling the physical location of the treatment with emphasis on the pleural cavity.

Many advanced techniques in cancer treatment are tried on mesothelioma patients because of its high fatality rate. These include biologic therapy such as the agent interleukin 2 and anti-angiogenesis drugs such as thalidomide. The new drug pemetrexed (brand name Alimta) has shown good results in extending life with mesotheliomas..

Before acting, oncologists review the stage of mesothelioma, position of the tumor, and age and health status of the patient. Two therapies that are extremely cutting-edge in fighting cancer are called photodynamic and gene therapy. Patients afflicted with mesothelioma are benefitting in these clinical trials.

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